Fisher's daughter, Billie Lourd, released a statement through her spokesman saying Fisher died Tuesday just before 9 a.m PST. Lourd said her mother was "loved by the world and she will be missed profoundly."
Fisher had been hospitalized since Friday when she suffered a medical emergency on board a flight to Los Angeles.
She made her feature film debut opposite Warren Beatty in the 1975 hit "Shampoo" and was also an accomplished author who detailed her experiences with addiction and mental illness in several best-selling books. Besides her daughter, Fisher is survived by her brother, Todd Fisher, and her mother, actress Debbie Reynolds.